ABIM Hematology

Practice session

A 70-year-old with macrocytic anemia (MCV 110 fL), neutropenia (ANC 1.1), and thrombocytopenia (plt 85) has hypercellular marrow with dysplasia in all three lineages and 4% blasts. Karyotype shows isolated del(5q). Which therapy is FDA-approved specifically for this cytogenetic finding?

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