ABP Pediatric Endocrinology

Practice session

A 9-year-old presents with polyuria, polydipsia, and 5 kg weight loss over 3 weeks. Glucose is 412 mg/dL, pH 7.18, HCO3 10, ketones large, and islet autoantibodies are positive for GAD65, IA2, and ZnT8. Which statement best characterizes the immunologic basis of this disease?

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