Arab Board Clinical Pathology Part 1

Practice session

A 16-year-old boy presents with mild jaundice, splenomegaly, and a family history of gallstones at young age. Blood film reveals prominent microspherocytes lacking central pallor, an elevated MCHC of 36.8 g/dL, and a negative Direct Antiglobulin Test (DAT). Which flow cytometric test is the diagnostic test of choice to confirm the erythrocyte membrane defect?

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