Anatomic Pathology Board
Saudi Board Final Written Examination - Anatomic Pathology (SCFHS)
Molecular PathologyEnglish
Exam overviewPractice session
In an oncology next-generation sequencing (NGS) assay performed on formalin-fixed paraffin-embedded (FFPE) tumor tissue, a pathogenic BRAF V600E (c.1799T>A) variant is identified. The bioinformatics pipeline reports a 'Depth of Coverage' of 850x and a 'Variant Allele Frequency' (VAF) of 34%. What do these two sequencing metrics specifically represent?
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